Although studies are still ongoing to determine potential interactions between CBD and specific medications, there’s one rule of thumb that can help consumers in the meantime: avoid CBD if your medications have a grapefruit warning on the label. This warning indicates that people taking the medication should avoid consuming grapefruit or grapefruit juice. According to the Food and Drug Administration, consuming grapefruit while on one of these medications can lead to a higher concentration of the medication in the bloodstream and adverse side effects or even an overdose. More than 85 drugs interact with grapefruit and some closely related citrus juices — like Seville oranges, pomelos, and tangelos. That’s because chemicals in grapefruit known as furanocoumarins inhibit CYP3A4, CBD works in a similar way. The result is a slowed metabolization of medications. Grapefruit warnings are common in several types of medications, but not all medications within a category will require the avoidance of grapefruit. Check your medication’s insert information or ask your doctor.